Skin care compositions containing fatty acid amides and retinol

Details Skin care compositions containing fatty acid amides and retinol Skin care compositions containing fatty acid amides and retinol

1995-05-08

1997-02-04

Hulina, Amy

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Cosmetic, antiperspirant, dentifrice

514725, 514844, 514859, A61K 3107, A61K 3116

Patent

active

055995489

ABSTRACT:
Fatty acid amides, but not free fatty acids or fatty acid esters, in combination with either retinol or retinyl ester resulted in a synergistic enhancement in keratinocyte proliferation and synergistic inhibition of keratinocyte differentiation. The effects of the retinol or retinyl esters in combination with fatty acid amides were analogous to treatment with retinoic acid.

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Vahlquist, A. et al., "Isotretinoin Treatment of Severe Acne Affects the Endogenous Concentration of Vitamin A in Sebaceous Glands", J. Invest. Dermatol., vol. 94, (1990), pp. 496-498.
Ellis, C. N. et al., "Treatment of Actinically Aged Skin with Topical Tretinoin", Pharmacology of Retinols in Skin, vol. 3, (1989), pp. 249-252.
Lowe, N. J. et al., "Systemic Retinoids in Psoriasis: Comparative Efficacy and Toxicity", Pharmacology of Retinols in Skin, vol. 8, (1989), pp. 240-248.
Derwent Abstract of WO 94/03156.
Derwent Abstract of EP 0 388 275.
Derwent Abstract of EP 0 559,304.

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