Methods for the cyto-protection of the trabecular meshwork

Details Methods for the cyto-protection of the trabecular meshwork Methods for the cyto-protection of the trabecular meshwork

1995-06-07

1997-02-04

Azpuru, Carlos

Drug, bio-affecting and body treating compositions

Topical body preparation containing solid synthetic organic...

Ophthalmic preparation

424423, 424443, 424450, 424451, 424464, 514912, 514913, 514914, 514915, A61K 3174, A61K 970, A61K 9127, A61F 202

Patent

active

055995357

ABSTRACT:
The invention concerns the recognition that certain non-steroidal anti-inflammatory agents produce cytoprotective effects on trabecular cells, and thus can be used to prevent injury to the cells and treat the loss of trabecular cells caused by oxidative or other forms of injury to the cells. Such treatment can ameliorate the severity, or prevent, glaucoma.

REFERENCES:
patent: 2798053 (1957-07-01), Brown
patent: 3732865 (1973-05-01), Higuchi et al.
patent: 3773919 (1973-11-01), Boswell et al.
patent: 3887699 (1975-06-01), Yolles
patent: 4136250 (1979-01-01), Mueller et al.
patent: 4192827 (1980-03-01), Mueller et al.
patent: 4327725 (1982-05-01), Cortese et al.
patent: 4454151 (1984-06-01), Waterbury
patent: 4522826 (1985-06-01), Sunshine et al.
patent: 4543251 (1985-09-01), Kamishita
patent: 4548990 (1985-10-01), Mueller et al.
patent: 4617299 (1986-10-01), Knepper
patent: 4670254 (1987-06-01), Kamishita
patent: 4690927 (1987-09-01), Voss et al.
patent: 4711782 (1987-12-01), Okada et al.
patent: 4711906 (1987-12-01), von Stetten et al.
patent: 4757060 (1988-07-01), Lukacsko et al.
patent: 4757089 (1988-07-01), Epstein
patent: 4777174 (1988-10-01), Sunshine et al.
patent: 4829088 (1989-05-01), Doulakas
patent: 4855293 (1989-08-01), Collington et al.
patent: 4876250 (1989-10-01), Clark
patent: 4880742 (1989-11-01), Hayaishi et al.
patent: 4904649 (1990-02-01), Schwartz
patent: 4917886 (1990-04-01), Asche et al.
patent: 4948805 (1990-08-01), Ziggiotti et al.
patent: 4960799 (1990-10-01), Nagy
patent: 4971802 (1990-11-01), Tarcsay et al.
patent: 4973469 (1990-11-01), Mulligan et al.
patent: 4980170 (1990-12-01), Schneider et al.
patent: 4999379 (1991-03-01), Fankhauser
patent: 5036097 (1991-07-01), Floyd et al.
patent: 5110493 (1992-05-01), Cherng-Chyi et al.
patent: 5124154 (1992-06-01), Babcock et al.
patent: 5190762 (1993-03-01), Yarosh
patent: 5192535 (1993-03-01), Davis et al.
patent: 5200453 (1993-04-01), Janssen
patent: 5270052 (1993-12-01), Gelfand et al.
patent: 5304561 (1994-04-01), Faezeh
patent: 5314909 (1994-05-01), Dollerup
patent: 5474985 (1995-12-01), Polansky et al.
Synder, R. W. et al. "Corticosteroid treatment and trabecular meshwork proteases in cell and organ culture supernatents", Exp. Eye. Res., 57:4 461-468 (1993).
Database Pharma Projects, PJB Publications Ltd., Dialog File 928 Accession Nr. 021312, (1996).
Gerritsen et al., "Prostaglandin Synthesis and Release from Cultured Human Trabecular Meshwork Cells and Scleral Fibroblasts". Exp. Eye. Res. 43:1089-1102 (1986).
Herbort et al., "Anti-inflammatory Effect of Topical Diclofenac After Argon Laser Trabeculoplasty", Klin Mbl. Augenheik, 200:358-361 (1992).
InSite Vision Annual Report (1993).
Polansky, J. R., et al. In Vitro Studies of Human Trabecular Cells: Perspectives and Limitations, Proc. Int. Soc. for Eye Research, vol. I, p. 3 (1980).
Polansky, J. R., et al. Glucocorticoid Receptors and Steroid Glaucoma Mechanisms, Encounters in Glaucoma Research I: Receptor Biology and Glaucoma, pp. 273-299 (Feb. 1994).
Alvarado, J. A. et al.-Human Trabecular Cells, Invest. Ophthalmol. Vis. Sci. 23:464-478 (1982).
Babizhayev, M. A. et al.-Lipid Peroxidation in Open-angle Glaucoma, Invest. Ophthalmol. Vis. Sci. 67:371-377 (1989).
Bengtsson, B.-Incidence of Manifest Glaucoma, British J. of Ophthalmology, 73:483-487 (1989).
Bhuyan, K. C. et al.-Regulation of Hydrogen Peroxide in Eye Humors: Effect of 3-Amino-1H-1,2,4-Triazole on Catalase and Glutathione Peroxidase of Rabbit Eye, Biochmica et Biophysica Acta 497:641-651 (1977).
Bhuyan, K. C. et al-Mechanism of Cataractogenesis Induced by 3-amino-1H-1, 2, 4-triazole. I: Morphology and Histopathology of Cataract and the Role of Catalase in the Regulation of H202 in the Eye, Biochemical and Clinical Aspects of Oxygen, 785-796 (1979).
Clark, A. F.-Evaluation of Anti-Glaucoma Compounds And Discovery Of Pathogenic Mechanisms Using Perfusion Cultured Human Eyes, Exp. Eye Res. 55:266 (1992).
Ellis, P. P.-Basic Considerations (Chap. 1), Therapy of Diseases of the Cornea (Chap. 11), Therapy of Glaucomas (Chap 13), Ocular Therapeutics and Pharmacology, pp. 3-27, 137-157, 162-186 (7th ed 1985).
Epstein, D. L.-Chandler and Grant's Glaucoma, pp. 3-5, 129-143, 181-183, 191, 194-195, 201-210, 211, 293-294, 311, 320-321, 352-379, 396 and 403-407 (3d ed. 1986).
Flach, A. J.-Cyclo-oxygenase Inhibitors in Opthalmology, Survey of Ophthalmology, 36:259-284 (1992).
Fauss, D. J. et al.-Glucocorticoid (GC) Effects on HTM Cells: Biochemical Approaches and Growth Factor Responses, Basic Aspects of Glaucoma Research III, pp. 319-330 (1993).
Giblin, F. J. et al.-The Role of Glutathione Metabolism in the Detoxification of H202 in Rabbit Lens, Invest. Ophthalmol. Vis. Sci. 22:330-335 (1982).
Huk, B. et al.-Anti-Inflammatory Treatment after Argon Laser Trabeculoplasty, Ophthalmologica 203:24-29 (1991).
Insel, P. A. et al.-Analgesic-Antipyretics and Antiinflammatory Agents; Drugs Employed in the Treatment of Rheumatoid Arthritis and Gout, Goodman and Gilman's The Pharmacological Basis of Therapeutics, pp. 638-641 (8th ed. 1990).
Kahn, M. G. et al.-Glutathione in Calf Trabecular Meshwork and its Relation to Aqueous Humor Outflow Facility, Invest. Ophthalmol. Vis. Sci. 24:1283-1287 (1983).
Klemetti, A.-The Dexamethason Provocative Test: A Predictive Tool for Glaucoma?, Acta Ophthalmol. 68:29-33 (1990).
Langer, R.-Controlled Release of Macromolecules, Chem. Tech. 12:98-105 (1982).
Lee, V. H. L.-Review: New Directions in the Optimization of Ocular Drug Delivery, J. Ocular Pharmacol. 6:157-164 (1990).
Leske, M. C. et al.-Estimating Incidence from Age-Specific Prevalence in Glaucoma, Amer. J. Epidemiol. 113:606-613 (1981).
Lombardino, J. G.-Nonsteroidal Anti-inflammatory Drugs. Chapter Two: Inflammation- Mechanisms and Mediators, pp. 75-109 (1985).
McGraw-Hill Encyclopedia of Science and Technology: Eye (vertebrate) 8:544-552 (6th ed. 1987).
McGraw-Hill Encyclopedia of Science and Technology: Glaucoma 8:131-132 (6th ed. 1987).
Mullins, J. D. et al.-Ophthalmic Preparations, Remington's Pharmaceutical Sciences, Chap. 86, pp. 1581-1595 (18th ed. 1990).
Nguyen, K. P. et al.-Hydrogen Peroxide Removal by the Calf Aqueous Outflow Pathway, Invest. Ophthalmol. Vis. Sci. 29:976-981 (1988).
Nguyen, T. D. et al.-Glucocorticoid (GC) Effects on HTM Cells: Molecular Biology Approaches, Basic Aspects of Glaucoma Research III, pp. 330-343 (1993).
Polansky, J. R. et al.-Cellular Mechanisms Influencing the Aqueous Humor Outflow Pathway, Principles and Practice of Ophthalmology, Chap. 13, pp. 226-251 (1994).
Polansky, J. R. et al.-Cellular Injury from Sustained vs. Acute Hydrogen Peroxide Exposure in Cultured Human Corneal Endothelium and Human Lens Epithelium, CLAO Journal Supp. 16:S23-S29 (1990).
Polansky, J. R. et al.-Human Trabecular Cells, Invest. Ophthalmol. Vis. Sci. 18:1043-1049 (1979).
Polansky, J. R. et al.-Studies on Human Trabecular Cells Propagated in Vitro, Vision Res. 21:155-160 (1981).
Polansky, J. R. et al.-In Vitro Correlates of Glucocorticoid Effects on Intraocular Presszure, Glaucoma Update IV, pp. 20-29 (1991).
Polansky, J. R. et al.-Eicosanoid Production and Glucocorticoid Regulatory Mechanisms in Cultured Human Trabecular meshwork Cells, The Ocular Effects of Prostaglandins and other Eicosanoids, pp. 113-138 (1989).
Polansky, J. R.-Side Effects of Topical Ophthalmic Therapy With Anti-Inflammatory Steroids and B-Blockers, Current Opinion in Ophthalmology 3:259-272 (1992).
Polansky, J. R. et al.-Growth Factor Effects and Modulation of Glucocorticoid (GC) and Other Stress Responses in Human Trabecular Meshwork (HTM) Cells, Experimental Eye Research 55:265 (1992).
Polansky, J. R.-Basic Pharmacology of Corticosteroids, Current Topics in Ocular Inflammation, No. 1, pp. 9-21 (1993).
Polansky, J. R. et al.-HTM Cell Culture Model For Steroid Effects on Intraocular Pressure: Overview, Basic Aspects of Glaucoma Research III, pp. 307-318 (1993).
Polansky, et al.-Anti-Inflammatory Agents: Steroids as Anti-Inflammatory Agents, Handbook of Experimental Pharmacology 69:491-503 (1984).
Polansky, et al.-Cellular Sensitivi

Affiliated with

Also associated with

Rating

Methods for the cyto-protection of the trabecular meshwork does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for the cyto-protection of the trabecular meshwork, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for the cyto-protection of the trabecular meshwork will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-676056