Sulphonamidocycloalkane compounds, pharmaceutical compositions c

Details Sulphonamidocycloalkane compounds, pharmaceutical compositions c Sulphonamidocycloalkane compounds, pharmaceutical compositions c

1992-06-30

1995-04-18

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514459, 514471, 514522, 514524, 514538, 514562, 514575, 549293, 549323, 558413, 560 10, 560 12, 562427, 562430, 562621, 562622, 564 84, 564 86, 564 90, 564 93, A61K 3118, C07C31116, C07C31117

Patent

active

054079519

ABSTRACT:
The present invention provides sulphonamides of the general formula: ##STR1## wherein R.sup.1 and R.sup.2, which can be the same or different, are hydrogen or halogen atoms or C.sub.1 -C.sub.6 -alkyl, trifluoro-methyl, cyano, carboxyl, alkoxycarbonyl, aminocarbonyl, N-alkylaminocarbonyl or N,N-dialkylaminocarbonyl radicals or, when R.sup.1 and R.sup.2 are alkyl radicals ortho to one another, R.sup.1 and R.sup.2 together with the carbon atoms to which they are attached, form a saturated or unsaturated C.sub.5-C.sub.7 -alkylene ring, R.sup.3 is a hydrogen atom, an alkyl radical containing up to 6 carbon atoms, an acyl radical, a phenylalkyl or phenylalkenyl radical, the phenyl moiety of which can be substituted by halogen, alkyl or trifluoromethyl, C is a --(CH.sub.2).sub.m --radical, in which m is 0, 1, 2 or 3, or a branched C.sub.2 -C.sub.5 -alkylene radical, whereby a methylene radical --CH.sub.2 --of the group C can be replaced by an oxygen or sulphur atom or by a hydroxymethylene radical --CHOH--or carbonyl group --CO--, B is a 1,2-, 1,3-, 1,4-cyclohexylidene or 1,2- or 1,3-cyclopentylidene radical.

REFERENCES:
King et al, Chemical Abstracts, vol. 52 (1958) 7334h.
Uloth et al, Chemical Abstracts, vol. 64 (1966) 4980c.
Berger et al, Chemical Abstracts, vol. 69 (1968) 2543c.
Okano et al, Chemical Abstracts, vol. 77 (1972) 156v.
Prout et al, Chemical Abstracts, vol. 78 (1973) 146998p.
Armarego et al, Chemical Abstracts, vol. 82(1975) 125345r.
Schultz et al, Chemical Abstracts, vol. 107 (1987) 198718j.
Uloth et al, J. Med. Chem., vol. 9, No. 1 (1966) pp. 88-97.
Okano et al, J. Med. Chem., vol. 15, No. 3(1972) pp. 247-255.

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