Substituted phenoxyalkyl quaternary ammonium compounds as antiar

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...

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424263, A61K 3144, A61K 31445

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active

040498140

ABSTRACT:
Quaternary ammonium compounds such as [2-(4-amino-2,6-dibromophenoxy)ethyl]dimethyl (allyl) ammonium bromide are prepared by the reaction of a tertiary amine such as 3,5-dibromo-.beta.-dimethylamino-p-phenetidine with a substituted organic compound such as allyl bromide. The quaternary ammonium compounds are useful in alleviating or inhibiting cardiac arrhythmias when the quaternary ammonium compounds, or compositions comprising the same are administered to animals.

REFERENCES:
patent: 2895995 (1959-07-01), Willey et al.
patent: 3453313 (1969-07-01), Margot et al.
Hey; Brit. J. Pharmacol. 7, (1952), pp. 117-129.
Hey et al., Brit. J. Pharmacol. 9, (1954), pp. 471-475.
Jones et al., Biochem. J. 45 (1949), pp. 143-149.

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