Novel pregnanoic acid derivatives

Details Novel pregnanoic acid derivatives Novel pregnanoic acid derivatives

1976-03-19

1977-09-20

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2603971, 26023955D, A61K 3156, C07J 2100

Patent

active

040498042

ABSTRACT:
Pregnanoic acid derivatives of general formula ##STR1## wherein is a single bond or a double bond; X is hydrogen, fluorine or methyl; Y is hydrogen, fluorine or chlorine; Z is .beta.-hydroxymethylene, .beta.-acyloxymethylene, .beta.-fluoromethylene, .beta.-chloromethylene, carbonyl or methylene; R.sub.1 is hydrogen, methyl in the .alpha.- or .beta.-position or methylene and R.sub.2 is hydrogen, hydroxy or acyloxy, or R.sub.1 and R.sub.2 collectively are alkylidendioxy and U.sub.1 is halogen, halogenated alkyl of 1-5 carbon atoms or halogenated phenyl, are topically effective anti-inflammatory agents.

REFERENCES:
patent: 3833563 (1974-09-01), Laurent et al.
patent: 3856828 (1974-12-01), Phillipps et al.
patent: 3906095 (1975-09-01), Laurent et al.
patent: 3944577 (1976-03-01), Laurent et al.

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