2-Amino-4,5-dihydropyridine derivatives in pharmaceutical compos

Details 2-Amino-4,5-dihydropyridine derivatives in pharmaceutical compos 2-Amino-4,5-dihydropyridine derivatives in pharmaceutical compos

1974-12-12

1976-11-16

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

A61K 31455

Patent

active

039925455

ABSTRACT:
2-Amino-4,5-dihydropyridines-3,5-dicarboxylates substituted by lower alkoxy or lower alkylthio in the 6-position and optionally substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are antihypertensive agents and coronary vessel dilators. The compounds, of which 2-amino-4-(3-nitrophenyl)-6-ethoxy-4,5-dihydropyridine-3,5-dicarboxylic acid diethyl ester is a representative embodiment, are prepared through condensation of an aldehyde and a 3-aminoacrylate bearing an alkoxy or alkylthio group in the 3-position.

REFERENCES:
patent: 3708489 (1973-01-01), Rucker et al.
patent: 3773773 (1973-11-01), Bossert
patent: 3775422 (1973-11-01), Bossert et al.

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