Process for .alpha.-C-alkylation of the 8-acyl group on mevinoli

Details Process for .alpha.-C-alkylation of the 8-acyl group on mevinoli Process for .alpha.-C-alkylation of the 8-acyl group on mevinoli

1987-07-10

1989-04-11

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

556419, C07D30910

Patent

active

048208507

ABSTRACT:
A process for alkylating the alpha position of the 8-acyl side chain in mevinolin and analogs thereof is disclosed. The process proceeds with a single charge of base and alkyl halide to give products with a pharmaceutically acceptable purity.

REFERENCES:
patent: 4444784 (1984-04-01), Hoffman et al.
patent: 4582915 (1986-04-01), Sletzinger et al.
patent: 4584389 (1986-04-01), Sletzinger et al.
patent: 4588820 (1986-05-01), Stokker et al.
Newton et al., "An Excellent Reagent for the, etc." CA92:214927f (1980).

Affiliated with

Also associated with

Rating

Process for .alpha.-C-alkylation of the 8-acyl group on mevinoli does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for .alpha.-C-alkylation of the 8-acyl group on mevinoli, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for .alpha.-C-alkylation of the 8-acyl group on mevinoli will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-668405