Preparation of a highly pure, substantially amorphous form of ce

Details Preparation of a highly pure, substantially amorphous form of ce Preparation of a highly pure, substantially amorphous form of ce

1986-12-04

1989-04-11

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540222, A61K 31545, C07D50124

Patent

active

048208337

ABSTRACT:
There is described a product which is a highly pure substantially amorphous form of cefuroxime axetil (cefuroxime 1-acetoxyethyl ester) which is stable, which has increased absorption via the gastro-intestinal tract and has a correspondingly high level of bioavailability on oral or rectal administration.
Methods of preparing the product are also described which involve the recovery of the product from a solution thereof. A preferred method is the use of spray drying techniques, though roller drying, solvent precipitation or freeze-drying are also described.
Also disclosed are pharmaceutical compositions containing the product and methods for its use in medicine.

REFERENCES:
patent: 4029655 (1977-06-01), Cise
patent: 4267320 (1981-05-01), Gregson et al.
patent: 4562181 (1985-12-01), Crisp et al.
Chem Pharm. Bull., 29(9), pp. 2675-2682 (1961) Sato.

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