Process of producing .alpha.-keto acids

Details Process of producing .alpha.-keto acids Process of producing .alpha.-keto acids

1986-02-21

1989-04-11

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546327, 549 79, 549436, 549488, 560254, 562406, 562520, C07C 5110

Patent

active

048208230

ABSTRACT:
In accordance with a process of the present invention, .alpha.-keto acids of the general formula RCOCOOH wherein R is aryl, alkenyl or heterocyclic group, can be obtained through one-step carbonylation reaction of an organic halogenide of the general formula RX wherein R is the same as above and X is a halogen atom, with carbon monoxide and water in the presence of a basic compound and a palladium containing catalyst.

REFERENCES:
patent: 4152352 (1979-05-01), Perron
patent: 4473706 (1984-09-01), Lee et al.
patent: 4480121 (1984-10-01), Klun
patent: 4608816 (1987-05-01), Epstein
patent: 4689431 (1971-08-01), Tanka
patent: 4738802 (1988-04-01), Lee
Schoenberg et al., J. Org. Chem. 39, 3319 (1974).
Falbe, CO in Organic Synthesis, pp. 78, 118, 119 (1967).
Ozawa, Chemistry Letters (5), 567 (1985).
Tanaka, J. Mol. Catal. 32, 115 (1985).
Ozawa et al., "Double Carbonylation Reactions of . . . ", Chemistry Letters, pp. 865-868, 1982.
Fell et al, "Carbonylierung von Alkylhalogeniden . . . ", Chemiker-Zeitung, May 1985, pp. 167-170.
Fell et al., "Bildung von .alpha.-Ketocarbonsauren . . . ".
Ozawa et al., "Catalytic Double Carbonylation . . . ", Tetrahedron Letters, vol. 23, No. 33, pp. 3383-3386 (1982).
Francalanci et al., "Phase-Transfer Catalysis in Cobalt . . . ", Journal of Organometallic Chemistry, 232 (1982) 59-70.
Ozawa et al., "Palladium-Catalyzed Double Carbonylation . . . ", J. Am. Chem. Soc. 1985, 107, 3235-3245.

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