Tricyclic derivatives of substituted pyrrole acids as analgesic

Details Tricyclic derivatives of substituted pyrrole acids as analgesic Tricyclic derivatives of substituted pyrrole acids as analgesic

1982-06-04

1984-04-03

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

2602393T, 548427, 548430, 548431, 548450, A61K 3155, C07D20994, C07D491044

Patent

active

044407793

ABSTRACT:
Tricyclic derivatives of substituted pyrrole acids, e.g., substituted 4,10-dihydro-10-oxo-1H-[1]benzoxepino[4,3-b]pyrrole-2-acetic acids or the 5-thia analogs thereof have been prepared via hydrolysis of a precursor or decarboxylation of a precursor-diacid. These tricyclic compounds are found to have high analgesic and anti-inflammatory activities but low ulcerogenic side effects.

REFERENCES:
patent: 3952012 (1976-04-01), Carson
patent: 4119639 (1978-10-01), Carson
Ackrell et al., J. Heterocyclic Chem., 17, 1081 (1980).

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