Multimeric antiviral agent

Details Multimeric antiviral agent Multimeric antiviral agent

1994-10-04

2000-08-01

Chan, Christina Y.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530325, 530326, 530327, 530328, 530329, 530350, 530395, 530402, 530345, 514 12, 514 13, 514 14, 514 15, 514 16, 514 17, 4241851, C07K 500

Patent

active

060968621

ABSTRACT:
Multimeric antiviral agents comprising two or more monomers selected from the group consisting of monomers of transmembrane intracellular adhesion molecule-1 (tmICAM-1) and truncated intercellular adhesion molecule-1 (tICAMs), with the proviso that when said multimer is a dimer said monomers cannot both be tmICAM-1, wherein each of said monomers comprises the human rhinovirus (HRV) binding site and retains the ability to bind to HRV and reduce infectivity thereof, and wherein said multimeric antiviral agent mimics the multimeric configuration of tmICAM-1 and exhibits enhanced binding to said HRV relative to at least one of the constituent monomers.

REFERENCES:
patent: 4171365 (1979-10-01), Diana et al.
patent: 4209526 (1980-06-01), Diana et al.
patent: 4232161 (1980-11-01), Diana et al.
patent: 4234725 (1980-11-01), Diana et al.
patent: 4261928 (1981-04-01), Diana et al.
patent: 4372976 (1983-02-01), Diana
patent: 4427653 (1984-01-01), Springer
patent: 4451476 (1984-05-01), Diana
patent: 4843087 (1989-06-01), Diana
patent: 4956281 (1990-09-01), Wallner et al.
patent: 5081228 (1992-01-01), Dower et al.
patent: 5109123 (1992-04-01), Reinherz et al.
patent: 5179017 (1993-01-01), Axel et al.
patent: 5235049 (1993-08-01), McClelland et al.
patent: 5240694 (1993-08-01), Gwaltney, Jr.
patent: 5284931 (1994-02-01), Springer et al.
patent: 5304636 (1994-04-01), Blaas et al.
patent: 5324510 (1994-06-01), Wegner et al.
patent: 5340800 (1994-08-01), Liu et al.
patent: 5349053 (1994-09-01), Landolfi
patent: 5359046 (1994-10-01), Capon et al.
patent: 5372933 (1994-12-01), Zamarron et al.
patent: 5395929 (1995-03-01), Corbi et al.
patent: 5422097 (1995-06-01), Gwaltney
patent: 5472849 (1995-12-01), Rothlein et al.
patent: 5475091 (1995-12-01), Springer et al.
patent: 5525487 (1996-06-01), Gallatin et al.
patent: 5532127 (1996-07-01), Gallatin et al.
patent: 5580969 (1996-12-01), Hoke et al.
patent: 5589453 (1996-12-01), Greve
patent: 5597567 (1997-01-01), Whitcup et al.
patent: 5603932 (1997-02-01), Blaas et al.
patent: 5612216 (1997-03-01), Springer et al.
patent: 5663293 (1997-09-01), Gallatin et al.
patent: 5674982 (1997-10-01), Greve et al.
patent: 5686581 (1997-11-01), Greve et al.
patent: 5686582 (1997-11-01), Greve et al.
patent: 5712245 (1998-01-01), Blaas et al.
patent: 5730983 (1998-03-01), Wegner et al.
patent: 5821341 (1998-10-01), McClelland et al.
patent: 5831036 (1998-11-01), Springer et al.
patent: 5849699 (1998-12-01), McClelland et al.
patent: 5871733 (1999-02-01), Greve et al.
Abraham, G. and Colonno, R. J., "Many Rhinovirus Serotypes Share the Same Cellular Receptor", J. Virol. 51:340-345 (1984).
Anasetti et al., "Activation of Natural Killer Cells by LFA-3 Binding to CD2", 4.sup.th International Conference on Human Leukocyte Differentiation Antigens, Vienna, Austria, Feb. 21-25, 1989, Tissue Antigens (1989) 33(2), 73.
Argenbright et al., "Monoclonal Antibodies to the Leukocyte Membrane CD18 Glycoprotein Complex and to Intercellular Adhesion Molecule-1 Inhibit Leukocyte-Endothelial Adhesion in Rabbits", J. Leukoc. Biol. 49:253-257 (1991).
Argenbright, L. W. and Barton, R. W., "Interactions of Leukocyte Integrins with Intercellular Adhesion Molecule-1 in the Production of Inflammatory Vascular Injury In Vivo: the Shwartzman Reaction Revisited", J. Clin. Invest. 89(1):259-272 (1992).
Badger et. al., "Structure Analysis of a Series of Antiviral Agents Complexed with Human Rhinovirus 14", PNAS 85:3304-3308 (1988).
Bangham, C. R. M. and McMichael, A. J., "Nosing ahead in the cold war" Nature 334:16 (1990).
Bebbington, C. R., and Hentschel, C. C. G. "The use of vectors based on gene amplification for the expression of cloned genes in mammalian cells" DNA Cloning 3:163-186 (1987).
Blann, A. D., "Cell Hybrids: an important new source o antibody production" Med. Lab. Sci. 36:329-338 (1979).
Bock et al., "Characterization of soluble forms of NCAM", FEBS Lett 225(1,2):33-36 (1987).
Bowie et al., "Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions", Science 247:1306-1310 (1990).
Campbell, B. A. and Cords, C. E., "Monoclonal Antibodies That Inhibit Attachment of Group B Coxsackieviruses", J. Virol. 48(2):561-564 (1983).
Capon et al., "Designing CD4 immunoadhesins for AIDS therapy", Nature 337:525-531 (1989).
Cate et al., "Isolation of the Bovine and Human Genes for Mullerian Inhibiting Substance and Expression of the Human Gene in Animal Cells", Cell 45:685-698 (1986).
Cole et al., "Topographic Localization of the Heparin-binding Domain of the Neural Cell Adhesion Molecule N-CAM", J. Cell Biol. 103:1739-1744 (1986).
Colonno et al., "Isolation of a Monoclonal Antibody that Blocks Attachment of the Major Group of Human Rhinoviruses", J. Virology 57:7-12 (1986).
Colonno, R. J. and Tomassini, J. E., "Viral Receptors: A Novel Approach For The Prevention Of Human Rhinovirus Infection", in Medical Virology VI, de la Maza, L. M. and E. M. Peterson, eds. (Elsevier, New York, 1987) 331-351.
Cooper, G.M., "Cellular Transforming Genes", Science 217: 801-806 (1982).
Couch, R.B., "Rhinoviruses", Virology, Second Edition, edited by B. N. Fields, D. M. Knipe et al. Raven Press, Ltd., New York, 607-629 (1990).
Couch et al., "Effect of Route Inoculation on Experimental Respiratory Viral Disease in Volunteers and Evidence for Airborne Transmission", Bacteriol. Rev. 30:517-529 (1966).
Creighton, T.E., Proteins by W. H. Freeman and Company, New York, 33-34 (1984).
Crump et al., "In Vitro Inhibitory Activity of Soluble ICAM-1 for the Numbered Serotypes of Human Rhinovirus", Antiviral Chemistry and Chemother. 4(6):323-327 (1993).
Cunningham et al., "Neural Cell Adhesion Molecule: Structure, Immunoglobulin-Like Domains, Cell Surface Modulation, and Alternative RNA Splicing", Science 236:799-806 (1987).
Cybulsky, M. I. and Gimbrone, Jr., M. A., "Endothelial Expression of a Mononuclear Leukocyte Adhesion Molecule During Atherogenesis", Science 251:788-791 (1991).
D'Alessio et al., "Short-Duration Exposure and the Transmission of Rhinoviral Colds", J. Inf. Dis. 150(2):189-193 (1984).
Deen et al., "A Soluble Form of CD4 (T4) Protein Inhibits AIDS Virus Infection", Nature 331:82-86 (1988).
Dick, E.C., "Experimental Infection of Chimpanzees with Human Rhinovirus Types 14 and 43", Proceedings Of The Society For Experimental Biology And Medicine 127:1079-1081 (1968).
Dochez et al., "Studies in the Common Cold. IV. Experimental Transmission of the Common Cold to Anthropoid Apes and Human Beings by Means of a Filtrable Agent", J. Exp. Med. 52:701-716 (1930).
Douglas et al., "Prophylactic Efficacy of Intranasal Alpha 2-Interferon Against Rhinovirus Infections in the Family Setting", The New England J. of Med. 314:65-70 (1986).
Douglas, R. G., "Pathogenesis of Rhinovirus Common Colds in Human Volunteers", Annals of Otology, Rhinology and Laryngology 79:563-571 (1970).
Dustin et al., "Induction by IL 1 and Inteferon-.gamma.: Tissue Distribution, Biochemistry, and Function of a Natural Adherence Molecule (ICAM-1)", J. Immunol. 137(1):245-254 (1986).
Dustin et al., "Supergene Families Meet in the Immune System" Immunology Today, 9(7 and 8):213-215 (1988).
Dustin et al., "Correlation of CD2 Binding and Functional Properties of Multimeric and Monomeric Lymphocyte Function-Associated Antigen 3", J. Exp. Med. 169:503-517 (1989).
Ey, P.L., et. al.,"Isolation of Pure IgG1, IgG2a, and IgG2b Immunoglobulins from Mouse Serum Using Protein A--Sepharose", Immunochemistry 15:429-436 (1978).
Fisher et al., "HIV Infection is Blocked in vitro by Recombinant Soluble CD4", Nature 331:76-78 (1988).
Fox et al., "Prevention of a Rhinovirus and Poliovirus Uncoating by WIN 51711, a New Antiviral Drug", Antimicrob. Ag. and Chemotherapy 30:110-116 (1986).
Galfrey et. al., "Antibodies to Major Histocompatibility Antigens Produced by Hybrid Cell Lines", Nature 266:550-552 (1977).
Gething, M.J. and Sambrook, J., "Construction of Influenza Haemagglutinin Genes that Code for Intracellular and Secreted Forms of the Protein" Nature 300:598-603 (1982).
Ginsberg et al., "Inhibition of Fibronectin Binding to Platelets by P

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