2,5-diaryl tetrahydrothiophenes and analogs thereof as PAF-antag

Details 2,5-diaryl tetrahydrothiophenes and analogs thereof as PAF-antag 2,5-diaryl tetrahydrothiophenes and analogs thereof as PAF-antag

1985-09-13

1988-07-12

Siegel, Alan

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549 75, 549 77, 549 78, 549 79, 549 80, A61K 3138, C07D33312

Patent

active

047570849

ABSTRACT:
Analogs of 2,5-Diaryl tetrahydrothiophenes which were substituted or unsubstituted on 3,4-positions were prepared.
These compounds are found to be leukotriene inhibitors and potent and specific PAF (Platelet Activating Factor) antagonists. They are therefore useful in the treatment of various diseases or disorders mediated by the leukotriene and/or PAF, for example, inflammation, cardiovascular disorder, asthma, lung edema, adult respiratory distress syndrome, pain, and aggregation of platelets.

REFERENCES:
patent: 2439345 (1948-04-01), Morris
patent: 3644399 (1969-05-01), Brown et al.
patent: 3655692 (1972-04-01), Shen
Parnes, Chem. Abst. 90: 87166p (1979).
Biftu et al., J. Chem. Soc. 1147 (1978).
Biftu et al., J. Chem. Soc. 2276 (1979).

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