Novel pyrrolidinylamide ester derivatives having anti-prolyl end

Details Novel pyrrolidinylamide ester derivatives having anti-prolyl end Novel pyrrolidinylamide ester derivatives having anti-prolyl end

1986-12-01

1988-07-12

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548540, A61K 3140, C07D29518

Patent

active

047570830

ABSTRACT:
A novel pyrrolidinylamide ester derivative that exhibits inhibitory activity against prolyl endopeptidase, methods for synthesis thereof and its use as an inhibitor against said enzyme are disclosed. The pyrrolidinylamide ester of the invention has the following general formula: ##STR1## wherein n is 0 or an integer of 1 to 7 and R is hydrogen atom or a straight or branched alkyl having 1 to 8 carbon atoms.

REFERENCES:
patent: 2956064 (1960-10-01), Kagan et al.
patent: 3801636 (1974-04-01), Horrom
patent: 4206122 (1980-06-01), Natarajan et al.
patent: 4334073 (1982-06-01), Diehr
patent: 4510142 (1985-04-01), Cousse et al.
Noller, "Chemistry of Organic Compounds", 3rd. ed. (1965), pp. 189,190,193.
Chemical Abstracts, vol. 90, No. 3 "N-(Substituted Aminoalkyl)-2-oxo-1-pyrrolidine acetamides" Jan. 15, 1979; 90:22798b; L'Italien et al.
The proceedings of the 1984 Annual Meeting of "The Agricultural Chemical Society of Japan", pp. 752-754.
Agric. Biol. Chem., 42(12), 2417-2419, (1978); Yoshimoto et al.

Affiliated with

Also associated with

Rating

Novel pyrrolidinylamide ester derivatives having anti-prolyl end does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Novel pyrrolidinylamide ester derivatives having anti-prolyl end, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel pyrrolidinylamide ester derivatives having anti-prolyl end will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-664780