Cyclic aryl hydroxamic acids, derivatives thereof and method of

Details Cyclic aryl hydroxamic acids, derivatives thereof and method of Cyclic aryl hydroxamic acids, derivatives thereof and method of

1986-11-28

1988-07-12

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546141, 546142, A61K 31235, C07D21722

Patent

active

047570784

ABSTRACT:
Cyclic aryl hydroxamic acids and derivatives thereof are provided having the structure ##STR1## wherein R is H or arylalkyl, and including acid-addition salts thereof. These compounds are useful as inhibitors of leukotriene production and as such are useful as antiallergy, anti-inflammatory and anti-psoriatic agents.

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Burcherer, Stohmann, C. 1904 I, 1012,--Blattchen.
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"Biochemical and Pharmacological Activities of Ono-3122, A Diuretic, and Ono-3144, A Novel Anti-Inflammatory Drug," Aishita et al.

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