Piperazinyl benzyl acids having antihistamine activity

Details Piperazinyl benzyl acids having antihistamine activity Piperazinyl benzyl acids having antihistamine activity

1986-02-24

1988-07-12

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544396, 544397, A61K 31495, C07D29500

Patent

active

047570741

ABSTRACT:
The present invention provides compounds of the formula (I): ##STR1## or salts, esters or amide derivatives thereof, wherein R.sub.1 is --CO.sub.2 H, --CH.dbd.CH--CO.sub.2 H, --(CH.sub.2).sub.n CO.sub.2 H, or --O--(CH.sub.2).sub.n CO.sub.2 H (n=1 to 4); R.sub.2 is C.sub.1.varies. alkyl or benzyl which is optionally substituted by a C.sub.1-4 alkyl group or groups; R.sub.3 is C.sub.1-4 alkoxy, C.sub.1-4 alkyl or halogen. Also provided are pharmaceutical formulations containing the compounds of the formula (I) and methods for the preparation of the compounds. The above mentioned compounds have antihistaminic activity.

REFERENCES:
patent: 2630435 (1953-03-01), Baltzly et al.
patent: 2636032 (1953-04-01), Weston et al.
patent: 2709169 (1955-05-01), Morren
patent: 2861072 (1958-11-01), Weston et al.
patent: 3868377 (1975-02-01), Raabe et al.
patent: 4146582 (1979-03-01), Maggioni
patent: 4397855 (1983-08-01), Sircar
Sircar, Chem. Abst., 100:6551k, (1984).
Meuldermans et al., Chem. Abst. 99:133255c.
Baltes et al., Chem. Abst, 98:34599r.

Affiliated with

Also associated with

Rating

Piperazinyl benzyl acids having antihistamine activity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Piperazinyl benzyl acids having antihistamine activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Piperazinyl benzyl acids having antihistamine activity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-664721