Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1999-02-03
2000-08-01
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514 63, 5142242, 5142265, 5142305, 5142338, 5142342, 5142345, 514258, 514302, 514318, 514321, 514322, 514367, 514373, 514376, 544 48, 544 63, 544 69, 544 91, 544105, 544127, 544137, 544229, 544236, 544280, 544350, 546 14, 546116, 546198, 548110, 548153, 548207, 548218, 548241, A61P 2516, A61P 2524, A61P 2528, A61K 3142, C07D26120, C07D49802
Patent
active
060967714
ABSTRACT:
An isoxazole compound having the following formula: ##STR1## wherein R.sup.1 represents hydrogen, halogen, alkyl, alkoxy, hydroxyl, alkylthio, amino, alkanoyl, alkanoylamino, alkanoyloxy, alkoxycarbonyl, carboxy, (alkylthio)thiocarbonyl, carbamoyl, nitro or cyano; R.sup.2 represents an amino; m is 2 or 3; n is 1 to 6; ring A represents a phenyl ring, a naphthyl ring or an aromatic heterocycle; and X represents oxygen or sulfur. The isoxazole compound has an excellent monoamine oxidase inhibitory activity, and is useful for treating Parkinson's disease, depression and Alzheimer's disease.
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T. Vitali, F. Mossini, G. Bertaccini and M. Impicciatore, "Proprieta Biologiche Di Composti 1,2-Benzisotiazolici", (1968), 1081-1096, Farmaco., Ed. Sci., 23 and English-language abstract thereof (CA, 70:37702).
T. Vitali, E. Gaetani, P. Mantovani and A. Agosti, "Proprieta Biologiche Di Composti 1,2-Benzisotiazolici", (1969), 440-448, Farmaco., Ed. Sci., 24 and English-language abstract thereof (CA 71:49831).
Aizawa Yuichi
Kaneko Isao
Kojima Koichi
Koyama Kazuo
Kozuka Masao
Coleman Brenda
Sankyo Company Limited
Shah Mukund J.
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