Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-08-14
2000-08-01
Jordan, Kimberly
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514422, 514443, A61K 31445, A61K 3140, A61K 3138
Patent
active
060967641
ABSTRACT:
A method of inhibiting detrimental side-effects of GnRH or GnRH agonist administration in a mammal which comprises the administration to a mannal in need thereof of an effective amount of a compound of formula I ##STR1## wherein R.sup.1 and R.sup.3 are, independently, --H, --CH.sub.3, --CO(C.sub.1 -C.sub.6 alkyl), or --COAr, where Ar is optionally substituted phenyl;
REFERENCES:
Evans, et al, Endocrinology, 137(10):4139-4144 (1996).
Black, et al, J. Clin. Ivest., 93(1):63-69 (1994).
Lips, et al, Nederlands Tijischrift Voor GeneeSkunde, 140(23):1215-1217 (1996).
Kauffman, et al, J. Pharma. Exp. Ther., 280 (1):146-153 (1997).
Wang, et al., Eur. J. Exp. Musculoskeletal Res., 4(3-4):171-175 (1995).
Frolik, et al., Bone, 18(6):621-627 (1996).
CA 109:86521, Ortmann et al., 1988.
CA 124:155994, Draper, Sep. 1995.
Bryant Henry Uhlman
Cullinan George Joseph
Dodge Jeffrey Alan
Eli Lilly and Company
Jordan Kimberly
Sales James J.
Voy Gilbert T.
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