Process for the preparation of ste specific 1'-spiro-nucleosides

Details Process for the preparation of ste specific 1'-spiro-nucleosides Process for the preparation of ste specific 1'-spiro-nucleosides

1994-06-24

1998-02-03

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 286, 536 287, 536 288, 536 2722, 544 1, 544 63, 544 65, 5483007, 5483014, C07H 3170, C07D49808

Patent

active

057145997

ABSTRACT:
The invention relates to a novel process for stereocontrolled preparation of 1',1'-disubstituted and 1'-spiro-nucleosides of the formula I ##STR1## in which the substituents A, R.sub.8 and R.sub.9 are as defined in claim 1, and to novel intermediates and their use in this process and to processes for the preparation of the novel intermediates. The process is illustrated by the example of biologically active (+)-hydantocidin.

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