Bis-heteroarylylmethoxyphenyl ketone derivatives as inhibitors o

Details Bis-heteroarylylmethoxyphenyl ketone derivatives as inhibitors o Bis-heteroarylylmethoxyphenyl ketone derivatives as inhibitors o

1996-09-17

1998-02-03

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514256, 514314, 514332, 546167, 546173, 546176, 546180, 546181, 546254, 546264, 546266, 544296, 544353, 544356, C07D21514, C07D21518, A61K 3147

Patent

active

057144885

ABSTRACT:
Compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein W is selected from the group consisting of optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted benzoxazolyl, optionally substituted benzimidazolyl, optionally substituted quinoxalyl, optionally substituted pyridyl, optionally substituted pyrimidyl, and optionally substituted thiazolyl; R.sup.1 and R.sup.2 are one or more groups independently selected from hydrogen, alkyl, halolalkyl, alkoxy, and halogen; Z is selected from the group consisting of N--OH, N--O--A--COM, CH--COM, and CH--CH.dbd.N--0--A--COM wherein A is selected from the group consisting of alkylene, alkenylene, cycloalkylene, and optionally substituted alkylphenyl wherein the alkyl portion is of one to six carbon atoms, and M is selected from the group consisting of a pharmaceutically acceptable, metabolically clearable group, --OR.sup.3, and --NR.sup.4 R.sup.5, inhibit leukotriene biosynthesis and are useful in the treatment of allergic and inflammatory disease states. Also disclosed are leukotriene biosynthesis inhibiting compositions and a method of inhibiting leukotriene biosynthesis.

REFERENCES:
patent: 4642347 (1987-02-01), Kreft
patent: 4970215 (1990-11-01), Mohrs et al.
patent: 4992576 (1991-02-01), Gapinski
patent: 5326883 (1994-07-01), Brooks et al.
patent: 5358955 (1994-10-01), Brooks et al.
patent: 5399699 (1995-03-01), Kolasa
Prasit, et al., Biorganic and Medicinal Chemistry Letters, 1 (11), (1991), 645-648.
Musser, J.H., and Kraft, A.F., Journal of Medicinal Chemistry, 35 (14), 1 (1992), pp. 2501-2523.

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