Process for the preparation of optically active carboxylic acids

Details Process for the preparation of optically active carboxylic acids Process for the preparation of optically active carboxylic acids

1992-07-01

1994-08-02

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 71, 549 72, 549425, 549484, 549486, 549487, C07D30716, C07D30908, C07D33324, C07D33502

Patent

active

053347307

ABSTRACT:
The present invention provides a process for the preparation of optically active carboxylic acids of the formula I* or II* ##STR1## in which X is an oxygen or sulfur atom and n is 1 or 2. The process comprises reacting a racemic carboxylic acid I or II or its derivatives with an optically active 2-amino-carboxylic acid ester to give the diastereomeric carboxylic acid amides, separating the diastereomers and, after cleavage of the amide bond, isolating the optically active carboxylic acids of the general formula I* or II*. The invention also provides certain novel optically active carboxylic acid amides and a tetrahydrothiopyran-2-carboxylic acid.

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