Alkyl-substituted-tricyclic quinazolinones for lowering blood pr

Details Alkyl-substituted-tricyclic quinazolinones for lowering blood pr Alkyl-substituted-tricyclic quinazolinones for lowering blood pr

1975-05-19

1976-10-05

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602564F, A61K 31505

Patent

active

039845567

ABSTRACT:
The compounds are alkyl-substituted-tricyclic quinazolinones of the class of imidazo[2,1-b]quinazolin-5-ones and pyrimido[2,1-b]quinazolin-6-one, e.g., 2-methyl-2,3-dihydro-10-(4'-fluorobenzyl)-imidazo[2,1-b]quinazolin-5(10H)- one, useful, for example, as bronchodilator agents. Processes for preparation of said compounds include the reaction of a N-carboxy anthranilic anhydride (an isatoic anhydride) with an alkyl substituted cyclic pseudothiourea such as a 2-organomercapto-4,5-dihydroimidazole or a 2-organomercapto-3,4,5,6-tetrahydropyrimidine and the cyclization of a 2-(.omega.-hydroxy(branched)alkylamino)-4-quinazolone.

REFERENCES:
patent: 3598823 (1971-08-01), Hardtmann
patent: 3621025 (1971-11-01), Jen et al.
patent: 3790573 (1974-02-01), Blackburn et al.
patent: 3833588 (1974-09-01), Hardtmann
Derwent, Abstract of Belgian Pat. No. 750,960 - issued 11/26/70.
Dolechall et al., "Chemical Abstracts," vol. 64 (1966), col. 6651e.

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