Prostaglandin E.sub.1 analogs

Details Prostaglandin E.sub.1 analogs Prostaglandin E.sub.1 analogs

1974-12-16

1976-10-05

Gerstl, Robert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602472R, 260268R, 26029365, 2603262, 260410, 2604299, 260430, 260439R, 260448R, 260488R, 2605011, 2605011S, 26050117, 2605012, 260514D, C07C17700

Patent

active

039844552

ABSTRACT:
This invention is a group of optically active or racemic prostaglandin E.sub.1 analogs of the formula: ##SPC1##
Wherein R is an alkyl group containing from one to 8 carbon atoms, inclusive, X is hydrogen or methyl with the proviso that not more than one methyl group can be present in a given side chain, Y and Y' are hydrogen or alkanoyl of one to 12 carbon atoms, inclusive, Z is hydrogen, a hydrocarbyl group of one to 12 carbon atoms, inclusive, or a pharmacologically acceptable cation, and n is 0, 1 or 2. These prostaglandin E.sub.1 analogs are useful for the same pharmacological purposes as PGE.sub.1.

REFERENCES:
eliel, Stereochemistry of Carbon Compounds, pp. 49-55, (1963).

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