Production of 4-hydroxy-1,2-benzothiazine-3-carboxamides

Details Production of 4-hydroxy-1,2-benzothiazine-3-carboxamides Production of 4-hydroxy-1,2-benzothiazine-3-carboxamides

1976-11-30

1978-06-13

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

424246, 260307H, 2602948F, 260295AM, 260559T, 260562N, 560 13, 2603068R, C07D27902

Patent

active

RE0296694

ABSTRACT:
A process for the synthesis of N-aryl-3,4-dihydro-2-alkyl-4-oxo-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides by treatment of N-aryl-N'-alkyl-N'-(2'-alkoxycarbonylbenzenesulfonyl)glycineamides, useful intermediates for said process, with an alkali or alkaline earth metal hydride in a reaction-inert solvent at 50.degree.-150.degree. C., said products being antiinflammatory agents.

REFERENCES:
patent: 3591584 (1971-07-01), Lombardino

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