Amino derivatives of [4,3-c]pyrazolopyridine carboxylic acids an

Details Amino derivatives of [4,3-c]pyrazolopyridine carboxylic acids an Amino derivatives of [4,3-c]pyrazolopyridine carboxylic acids an

1974-04-08

1976-10-05

Jiles, Henry R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260268BC, 2602936, C07D47106

Patent

active

039844226

ABSTRACT:
New amino derivatives of pyrazolo[4,3-c]pyridine-7-carboxylic acids and esters have the general formula ##SPC1##
Wherein R is hydrogen or lower alkyl; R.sub.1 is hydrogen, lower alkyl, phenyl or phenyl--(C.sub.1 -C.sub.2)-- lower alkyl; R.sub.2 is hydrogen, lower alkyl, phenyl or phenyl--(C.sub.1 -C.sub.2)-- lower alkyl; the group ##EQU1## forms one of the heterocyclic groups aziridono, pyrrolidino, piperidino, piperazino, 4-lower alkylpiperazino or 4-(hydroxy-lower alkyl)piperazino; R.sub.5 is hydrogen, lower alkyl or phenyl; and physiologically acceptable acid addition salts thereof.
They are useful as ataractic, analgesic and antiinflammatory agents. In addition, the new compounds increase the intracellular concentration of adenosine-3',5'-cyclic monophosphate.

REFERENCES:
patent: 3755340 (1973-08-01), Hoehn et al.

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