Process for synthesizing substituted 2-benzo [b]thiophenecarboxy

Details Process for synthesizing substituted 2-benzo [b]thiophenecarboxy Process for synthesizing substituted 2-benzo [b]thiophenecarboxy

1998-03-16

1999-10-12

Dentz, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D33070

Patent

active

059657499

ABSTRACT:
A process for the preparation of a substituted 2-benzo[b]thiophenecarboxylic acid compound or an alkali metal salt thereof, which comprises reacting a halobenzoyl derivative with mercaptoacetic acid in the presence of an alkali metal hydroxide and water. Substituted 2-benzo[b]thiophenecarboxylic acid compounds and alkali metal salts thereof are useful as intermediates for pharmaceuticals, agricultural chemicals, material preservatives, and the like.

REFERENCES:
patent: 5298630 (1994-03-01), Kagano
patent: 5777110 (1998-07-01), Davis
Rahman et al, J. Chem. Soc. Perkin Trans. I, pp. 385-390, 1984.
Kolasa et al, "Practical Synthesis of 2-Acetylbenz (b)thiophene", Syn. Comm. 23(6): 743-748 (1993).
Zambias et al, "The Synthesis of 5-Hydroxy-2,3-dihydrobenzob)thiophene (1) Via an Efficient One Step Preparation of 5-Nitro-Benzo(b)thiophene-2-Carboxylate (3A)", Syn. Comm. 21(7): 959-964 (1991).

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