Preparation of 4-methyl-5-[(2-aminoethyl)-thiomethyl]-imidazole

Details Preparation of 4-methyl-5-[(2-aminoethyl)-thiomethyl]-imidazole Preparation of 4-methyl-5-[(2-aminoethyl)-thiomethyl]-imidazole

1979-01-26

1980-02-19

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548146, C07D23364

Patent

active

041895924

ABSTRACT:
4-Methyl-5-[(2-aminoethyl)-thiomethyl]-imidazole dihydrochloride is prepared in a single-step process by thiomethylating 4-methylimidazole. The product is an intermediate for other imidazole derivatives, especially the drug cimetidine.

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Windaus, Berichte (Deutsche Chem. Gesellschaft) 1909, vol. 42, pp. 758-763.

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