Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1977-12-28
1980-02-19
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
548301, 548336, 544327, 544333, 546200, 26032625, 26032631, 424251, 424267, 424274, A61R 31415, C07D40312
Patent
active
041894936
ABSTRACT:
Disclosed are N-derivatives of thienamycin having structures I and II. ##STR1## wherein: the bifunctional radical may contain additional unsaturation in the ring; and wherein n is an integer selected from 1-6; p is 0, 1 or 2; R.sup.1 is selected from hydrogen, alkyl having 1-6 carbon atoms, and aryl having 6-10 carbon atoms; and Z is imino (.dbd.NH), oxo (.dbd.O), hydrogen, amino, or alkyl having 1-6 carbon atoms. Such compounds and their pharmaceutically acceptable salt and ester derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
REFERENCES:
patent: 3950357 (1976-04-01), Kahan et al.
patent: 4000161 (1976-12-01), Goegelman et al.
Christensen Burton G.
Hannah John
Shih David H.
Arno James A.
Harkaway Natalia
Levitt Julian S.
Mahon Frank M.
Merck & Co. , Inc.
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