Physiologically active substance esterastin

Details Physiologically active substance esterastin Physiologically active substance esterastin

1978-01-30

1980-02-19

Milestone, Norma S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424279, 435123, C07D30512

Patent

active

041894383

ABSTRACT:
A new physiologically active substance named esterastin is now provided, which inhibits the activity of esterase and is useful as an immunosuppressive drug. Esterastin is produced by cultivating a microorganism Streptomyces MD4-C1 identified as FERM-P 3723 or ATCC. 31336 in a culture medium under aerobic conditions and recovering it from the resulting culture. Esterastin is the compound having the formula ##STR1##

REFERENCES:
Journal of Systematic Bacteriology, vol. 18, p. 138 (1968).
S. A. Waksman, The Actinomycetes, vol. II, (1961), p. 234.
Int. J. Syst. Bacteriol, vol. 22(4), Oct. 1972, p. 276.
E. O. Stapley et al., Antimicrobial Agents and Chemotherapy (1963), pp. 20-27.
H. Umezawa et al., J. Antibiotics, vol. 31(6), (1978), pp. 639-641.
S. Kondo et al., J. Antibiotics, vol. 31(8), (1978), pp. 797-800.
K. Yamada et al., Tetrahedron, vol. 24, (1968), pp. 199-229.
D. C. Aldridge et al., J. Chem. Soc. (C), (1971), pp. 3888-3891.

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