Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1980-10-27
1982-06-22
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
546112, 546124, 260239BF, 2602444, 2602457, 424244, 424267, 424274, 548453, C07D45104, C07D45114, A61K 3146, A61K 31455
Patent
active
043362591
ABSTRACT:
Substituted benzamides having useful pharmacological properties, pharmaceutical compositions containing the same, pharmaceutically acceptable salts thereof, and procedure for administering said compositions. The active compounds have dopamine antagonist activity which is an effective amount of a compound of formula (I) and the compositions are particularly useful for the treatment of humans suffering from emesis impaired gastro-intestinal motility and disorders of the central nervous system. The administration of the compositions overcomes these disorders of the central nervous system and ordinary additions. The active compounds are characterized by having the formula (I), wherein R.sub.2 and/or R.sub.3 are sulphone groups, preferably either R.sub.2 or R.sub.3 being an aminosulphone or alkylsulphone group, which groups may optionally be substituted by 1 or 2 C.sub.1-6 alkyl groups.
REFERENCES:
patent: 4213983 (1980-07-01), Hadley
Minae et al., Chemical Abstracts, vol. 86, No. 25, 189,555z, Jun. 20, 1977.
Hadley Michael S.
King Francis D.
Beecham Group Limited
Rotman Alan L.
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