Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1996-02-21
1999-10-12
Fay, Zohreh
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
A61K 100
Patent
active
059655518
ABSTRACT:
A method of enhancing hair growth or treating alopecia in a subject uses topically administered estrogen receptor antagonists. Pharmaceutical formulations comprising estrogen receptor antagonists are described.
REFERENCES:
patent: 4139619 (1979-02-01), Chidsey, III
patent: 4596812 (1986-06-01), Chidsey, III et al.
patent: 4828837 (1989-05-01), Uster et al.
patent: 5026691 (1991-06-01), Kligman
patent: 5068315 (1991-11-01), Buultjens et al.
patent: 5177061 (1993-01-01), Pickart
patent: 5225189 (1993-07-01), Pena
patent: 5358714 (1994-10-01), Green
patent: 5395842 (1995-03-01), Labrie et al.
patent: 5407944 (1995-04-01), Goldman
patent: 5574048 (1996-11-01), Cullinan
patent: 5643942 (1997-07-01), Hester, Jr. et al.
A.E. Wakeling et al.; A Potent Specific Pure Antiestrogen with Clinical Potential, Cancer Res. 51:3867-3873 (1991).
J. Bowler et al.; Novel Steroidal Pure Antiestrogens, ICI Pharmaceuticals, Research Dept. (1988).
H. Jiang et al.; Induction of Anagen in Telogen Mouse Skin by Topical Application of FK506, a Potent Immunosuppressant, J. of Invest. Derm. 104:523-525 (1995).
J.P. Jacobs et al.; Use of Topical Minoxidil Therapy for Androgenetic Alopecia in Women, Int'l J. of Derm.32:758-762 (1993).
D.H. Rushton; Management of Hair Loss in Women, Derm. Therapy 11 No. 1:47-53 (1993).
G. Bazzano et al.; Effect of Retinoids on Follicular Cells, J. of Invest. Derm. 101 No. 1 (Supp):138S-142S (1993).
H. Uno et al.; Chemical Agents and Peptides Affect Hair Growth, J. of Invest. Derm. 101 No. 1 (Supp):138S-142S (1993).
W.S. Branham et al.; ICI 182,780 Inhibits Endogenous Estrogen-Dependent Rat Uterine Growth and Tamoxifen-Induced Developmental Toxicity, Bio. of Reproduct. 54:160-167 (1996).
C. Levesque et al.; Synthesis and Biological Activity of New Halo-Steroidal Antiestrogens, J. Med. Chem. 34:1624-1630 (1991).
A. Claussner et al.; 11.beta.-Amidoalkyl Estradiols, A New Series of Pure Antiestrogens, J. Steroid Biochem. Molec. Biol. 41 No. 3-8:609-614 (1992).
D. Poirier et al.; Synthesis and Antiestrogenic Activity of Diaryl Thioether Derivatives, J. Med. Chem. 37:1115-1125 (1994).
V.C. Jordan; Hydroxylated Antioestrogens: New Pharmacological Probes to Investigate Oestrogen and Antioestrogen Action, Hormone Antagonists 110-111 (1982).
J. Rosen et al.; Intracellular Receptors and Signal Transducers and Activators of Transcription Superfamilies: Novel Targets for Small-Molecule Drug Discovery, J. Med. Chem. 38 No. 25:4855-4874 (1995).
Oh Hye-Sun
Smart Robert C.
Fay Zohreh
North Carolina State University
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