Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Patent
1995-06-06
1999-10-12
Chin, Christopher L.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
435 71, 435 72, 435 721, 435 75, 435 79, 435 792, 435 794, 436501, 436524, 436525, 436526, 436527, 436528, 436529, 436531, G01N 33543
Patent
active
059654570
ABSTRACT:
Compounds and methods are provided for use in purification of CD34.sup.+ cells and specific surface antigens thereof. The present invention discloses methods for releasing CD34.sup.+ cells, as well as compounds having a carbohydrate epitope of the CD34 surface antigen, from an affinity matrix, using carbohydrates having the structure:
REFERENCES:
patent: 4714680 (1987-12-01), Civin
patent: 5032519 (1991-07-01), Paulson et al.
patent: 5081030 (1992-01-01), Civin
patent: 5215927 (1993-06-01), Berenson et al.
patent: 5225353 (1993-07-01), Berenson et al.
patent: 5262334 (1993-11-01), Berenson et al.
Kessler, "Epitope diversity and structure of the CD34 (p. 115) hematopoietic progenitor cell antigen," Naval Research Institute Federation Proceedings vol. 46, No. 4 1987, 6109.
Andrews et al., "Monoclonal Antibody 12-8 Recognizes a 115-kd Molecule Present on Both Unipotent and Multipotent Hematopoietic Colony-Forming Cells and Their Precursors," Blood 67 (3): 842-845, 1986.
Crocker et al., "Sialoadhesin Binds Preferentially to Cells of the Granulocytic Lineage," J. Clin. Invest. 95: 635-643, 1995.
Crocker et al., "Sialoadhesin, a macrophage sialic acid binding receptor for haemopoietic cells with 17 immunoglobulin-like domains," EMBO Journal 13: 4490-4503, 1994.
de Vries and van den Eijnden, "Biosynthesis of Sialyl-Oligomeric-Lewis.sup.X and VIM-2 Epitopes: Site Specificity of Human Milk Fucosyltransferase," Biochemistry 33: 9937-9944, 1994.
Srivastava and Hindsgaul, "Synthesis of Polylactosamine Oligomers By Disaccharide Polymerization," J. Carbohydrate Chemistry 10 (5): 927-933, 1991.
Sutherland et al., "CD34 Antigen: Molecular Features and Potential Clinical Applications," Stem Cells 11 (suppl. 3): 50-57, 1993.
Sutherland et al., "Cleavage of the Cell-Surface O-Sialoglycoproteins CD34, CD43, CD44, and CD45 By a Novel Glycoprotease From Pasteurella haemolytica," Journal of Immunology 148 (5): 1458-1464, 1992.
Sutherland et al., "Differential Sensitivity of CD34 Epitopes to Cleavage by Pasteurella haemolytica Glycoprotease: Implications for Purification of CD34-positive Progenitor Cells," Exp. Hematol. 20: 590-599, 1992.
Tomalia, D., "Dendrimer Molecules," Scientific American (May): 62-66, 1995.
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