Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1998-02-12
1999-10-12
Hendricks, Keith D.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
4352523, 43525233, 435325, 4353201, 435419, 43525411, 4352543, 536 232, 536 2431, C12N 920, C12N 1509, C12N 1570, C12N 1555
Patent
active
059654236
ABSTRACT:
The invention provides a human lysophospholipase (NHLP) and polynucleotides which identify and encode NHLP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of NHLP.
REFERENCES:
Wang A, et al. Cloning, expression, and catalytic mechanism of murine Lysophospholipase I. J Biol Chem. May 9, 1997; 272(19): 12723-12729.
Sugimoto, H. et al., "Purification, cDNA Cloning, and Regulation of Lysophospholipase from Rat Liver", J. Biol. Chem., 271: 7705-7711 (1996).
Selle, H. et al., "Glycerophosphocholine release in human erythrocytes 1H spin-echo and .sup.31 P-NMR evidence for lysophospholipase", Eur. J. Biochem., 212: 411-416 (1993).
Endresen, M.J. et al., "Increased lipolytic activity of sera from pre-eclamptic women due to the presence of a lysophospholipase", Scand. J. Clin. Lab Invest., 53: 733-739 (1993).
Anderson, R. et al., ".alpha.-Tocopherol Prevents Cyclosporin A-Mediated Activation of Phospholipase A.sub.2 and Inhibition of Na.sup.+, K.sup.+ -Adenosine Triphosphatase Activity in Cultured Hamster Renal Tubular Cells", Toxicol. Appl. Pharmacol., 125: 176-183 (1994).
Sugimoto, H. et al., (Direct Submission), GenBank Sequence Database (Accession D63885), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 1552243; GI 1552244) No Year Provided.
Sugimoto, H. and S. Yamashita, "Purification, Characterization, and Inhibition by Phosphatidic Acid of Lysophospholipase Transascylase from Rat Liver", J. Biol. Chem., 269: 6252-6258 (1994).
Wang, A. et al., (Direct Submission), GenBank Sequence Database (Accession U89352), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 1864158; GI 1864159) No Year Provided.
Hillman Jennifer L.
Murry Lynn E.
Shah Purvi
Hendricks Keith D.
Incyte Pharmaceuticals Inc.
Mayhew Bradley S.
Mohan-Peterson Sheela
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