DNA sequence encoding a tumor suppressor gene

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 6, 4353201, 435325, 435243, 435455, 536 231, 536 235, 536 2431, C12N 1500, C12N 1511, C12N 1585, C07H 2104

Patent

active

059653981

ABSTRACT:
The invention provides novel tumor suppressor genes, methods for making and using these and related tumor suppressor genes and proteins and peptides, and nucleic acids encoding these and related tumor suppressor proteins and peptides.

REFERENCES:
Aharon, T., et al., "Selective Destabilization of Short-Lived mRNAs with the Granulocyte-Macrophage Colony-Stimulating Factor AU-Rich 3' Noncoding Region is Mediated by a Cotranslational Mechanism", Mol. Cell. Biol., 13:1971-1980 (1993).
Atadja, P., et al., "Increased activity of p53 in senescing fibroblasts", Proc. Nat'l Acad. Sci. USA, 92:8348-8352 (1995).
Defeo-Jones, D., "Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product", Nature, 352:251-254 (1991).
El-Deiry, W.S., et al., "WAF1, a Potential Mediator of p53 Tumor Suppression", Cell, 75:817-825 (1993).
Garkavtsev, et al., "Suppression of the novel growth inhibitor p33.sup.ing1 promotes neoplastic transformation", Nature Genetics, 14(4):415-420 (1996).
Grudkov, A., et al., "Cloning mammalian genes by expression selection of genetic suppressor elements: Associate of kinesin with drug resistance and cell immortalization", Proc. Nat'l Acad. Sci. USA, 91:3744-3798 (1994).
Guan, K., et al., "Growth suppression by p18, a p16.sup.INK4/MTS1 and p14.sup.INK4B/MTS2 -related CDK6 inhibitor, correlates with wild-type pRb function", Genes & Dev., 8:2939-2952 (1994).
Gudkov, A.V., et al., "Isolation of genetic suppressor elements, inducing resistance to topoisomerase II-interactive cytotoxic drugs, from human topoisomerase II cDNA", Proc. Natl. Acad. ScI. USA, 90:3231-3235 (1993).
Harper, J.W., et al., "The p21 Cdk-Interacting Protein Cip1 is a Potent Inhibitor of G1 Cyclin-Dependent Kinases", Cell, 75:805-816 (1993).
Hillier, et al., "Database EMBL Entry HS12525", WashU-EST Project (Feb. 1995).
Hillier, et al., "Database EST on MPSRCH, Accession No. T60985", WashU-Merck EST Project (Feb. 1995).
Hunter, T., et al., "Cyclins and Cancer II: Cyclin D and CDK Inhibitors Come of Age", Cell, 79:573-582 (1994).
Kamb, A., et al., "A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types", Science, 264:436-440 (1994).
Levine, A.J., "The Tumor Suppressor Genes", Annu. Rev. Biochem., 62:623-651 (1993).
Lisitsyn, N. et al., "Cloning the Differences Between Two Complex Genomes", Science, 259:946-951 (1993).
Miller, A.D., et al., "Improved Retroviral Vectors for Gene Transfer and Expression", Biotechniques, 7:980-986 (1989).
Nobori, T., et al., "Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers", Nature, 368:753-756 (1994).
Riabowol, K., et al., "The cdc2 Kinase Is a Nuclear Protein That Is Essential for Mitosis in Mammalian Cells", Cell, 57:393-401 (1989).
Serrano, M., et al., "A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4", Nature, 366:704-707 (1993).
Straus, D., et al., "Genomic subtraction for cloning DNA corresponding to deletion mutations", Proc. Natl. Acad. ScI. USA, 87:1889-1893 (1990).
Weinberg, Robert A., "Tumor Suppressor Genes", Science, 254:1138-1146 (1991).
Yang, Y., et al., "An approach for treating the hepatobiliary disease of cystic fibrosis by somatic gene transfer", Proc. Nat'l. Acad. Sci. USA, 90: 4601-4605 (1993).
Yaswen, P., et al., "Down-regulation of a calmodulin-related gene during transformation of human mammary epithelial cells", Proc. Natl. Acad. ScI. USA, 87:7360-7364 (1990).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

DNA sequence encoding a tumor suppressor gene does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with DNA sequence encoding a tumor suppressor gene, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA sequence encoding a tumor suppressor gene will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-651287

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.