2-Aryl-2-[.omega.-(diis opropylamino)alkyl]-.omega.-(azabicycloa

Details 2-Aryl-2-[.omega.-(diis opropylamino)alkyl]-.omega.-(azabicycloa 2-Aryl-2-[.omega.-(diis opropylamino)alkyl]-.omega.-(azabicycloa

1977-03-11

1979-01-16

Berch, Mark L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260465E, 544349, 424244, 424250, 424267, 546112, C07D29512, C07D22122, C07D48704, A61K 31395

Patent

active

041348907

ABSTRACT:
Novel 2-aryl-2-[.omega.-(diisopropylamino)alkyl]-.omega.-(azabicycloalkyl)alkana mides are described herein. The present compounds are useful as anti-arrhythmic agents. The compounds are prepared by reacting an appropriate disubstituted acetonitrile with an appropriate .omega.-(azabicycloalkyl)alkyl halide and subsequent hydrolysis of the resulting nitrile with concentrated sulfuric acid.

REFERENCES:
patent: 3299044 (1967-01-01), Cusic et al.
patent: 3586713 (1971-06-01), Hoi et al.
Steseth et al., J. Org. Chem. 34, 3007-3010 (1969).
Pala et al., J. Med. Chem. 16, 720-723 (1973).
Casadio et al. I, J. Med. Chem. 9, 707-714 (1966).
Casadio et al. II, J. Med. Chem. 8, 594-598 (1965).
Borovicka et al., Chem. Abs. 52, 5335i (1957).
Blicke et al., J. Amer. Chem. Soc. 75, 4334-4335 (1953).
Instituto de Angeli, Derwent 14,754 of Dutch Patent 6,405,327, pub. 11-16-1964.

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