Serine/threonine protein kinase

Details Serine/threonine protein kinase Serine/threonine protein kinase

1997-03-14

1999-10-12

Carlson, Karen Cochrane

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435183, 435 691, 4353201, 435325, 536 232, C12N 900, C12P 2106, C07H 1700

Patent

active

059653655

ABSTRACT:
The present invention provides a human growth factor receptor binding protein (HSTPK) and polynucleotides which encode HSTPK. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for producing HSTPK and for treating disorders associated with expression of HSTPK.

REFERENCES:
Kentrup, H., et al., "Dyrk, a Dual Specificity Protein Kinase with unique Structural Features Whose Activity is Dependent on Tyrosine Residues Between Subdomains VII and VIII," The Journal of Biol. Chem., 271(7):3488-3495 (1996), XP-002069625.
Song, W., et al., Isolation of Human and Murine Homologues of the Drosophila Minibrain Gene: Human Homologue Maps to 21q22.2 in the Down Syndrome "Critical Region", XP-002069626.
TRHUM EMBL Database Entry Q92631, Accession Number Q92631; Feb. 1, 1997, Becker, W., et al., "Protein Kinase (fragment) DYRK4," XP002069627.
EMHUM1 EMBL Database entry HSDYRK4, Acession No. Y09305; Nov. 14, 1996, Becker, W., et al., "H. sapiens mRNA for protein kinase, Dyrk4, partial," XP002069628.
EMEST EMBL Database entry HSAA83586, Accession No. AA083586; Dec. 11, 1996, Hillier et al., "Homo sapiens cDNA clone 549128 5' similiar to WP:F49E11.1 CEO5897 serine/threonine protein kinase," XP002069629.
EMEST EMBL Database entry HS11443129, Accession No. AA223535; Feb. 22, 1997, Hillier et al., "Homo sapiens cDNA clone 650804 5' similar to SW:KA23 SCHPO Q09690 probable serine/threonine-protein," XP002069630.
EMEST EMBL Database entry HS116362, Accession No. W78116; Jun. 25, 1996, Hillier et al., "Soares fetal heart NbHH19W Homo sapiens cDNA clone 346879 3'", XP002069631.
EMEST EMBL Database entry HSAA83468, Accession No. AA083468; Dec. 11, 1996, Hillier et al., "Homo sapiens cDNA clone 549128 3'", XP002069632.
Hardie, G. et al., "The Eukaryotic Protein Kinase Superfamily" The Protein Kinase Facts Book (1995) vol. I:7-20.
Isselbacher, K.J. et al. (1994) Harrison's Principles of Internal Medicine, pp. 416-431 and 1887.
Egan, S.E., et al., "The pathway to signal achievement"Nature, (1993) 365:781-783.
Baynes, C. (GI 1246456), GenBank Sequence Database (Accession Z70308), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894. (GI 1246460).
Tejedor, F. et al., "minibrian: A New Protein Kinase Family Involved in Postembryonic Neurogenesis i Drosophila" Neuron (1995) 14:287-301. (GI 757822 and GI 757823).
Becker, W. et al. (GI 1669684) , GenBank Sequence Database (Accession Y09305), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894. (GI 1669685).

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