Substituted glutaric acid lactones in the treatment of hyperlipi

Details Substituted glutaric acid lactones in the treatment of hyperlipi Substituted glutaric acid lactones in the treatment of hyperlipi

1988-12-21

1990-01-23

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560126, 560179, C07C 6976, C07C 6974, C07C 6966

Patent

active

048959731

ABSTRACT:
Compounds of formula I ##STR1## are described which are useful to inhibit the formation of serum cholesterol by virtue of their ability to inhibit .beta.-hydroxy-.beta.-methylglutaryl-CoA(HMG CoA), the rate-controlling substance in the synthesis of serum cholesterol.

REFERENCES:
patent: 4607118 (1986-08-01), Grubbs et al.
Vanniedwenhuyze, F. et al, Chromatographic 23 (11), 860-5, 1987.

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