Process for producing 1-acyl-2-pyrazoline derivative

Details Process for producing 1-acyl-2-pyrazoline derivative Process for producing 1-acyl-2-pyrazoline derivative

1988-12-09

1990-01-23

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544406, 546256, 546279, 548379, C07D40312, C07D40112, C07D23106

Patent

active

048959472

ABSTRACT:
1-Acyl-2-pyrazoline derivatives represented by the formula ##STR1## where R.sup.1 denotes a hydrogen atom, pyridyl group, pyrazinyl group, alkyl group, aryl group, or alkoxy group; and R.sup.2, R.sup.3, and R.sup.4 independently denote a hydrogen atom, furyl group, pyridyl group, alkyl group, or aryl group, are produced by cyclizing by heating an acylhydrazone derivative represented by the formula ##STR2## where R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are defined as above, to produce compounds having useful anti-cerebral edema activity.

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Stapfer et al., J. Het. Chem., vol. 7, pp. 651-653, (1970).
Curtius et al., Ber. 27, 770 (1894).
J. Chem. Soc., 468 (1952), S. G. Beech et al, "Alicyclic Compounds. Part I. The Formation of Cyclopropanes in the Kishner-Wolff Reduction of .alpha..beta.. . . ".

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