Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1988-10-19
1990-01-23
Rizzo, Nicholas S.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
540200, 514192, C07D49904, A61K 31425
Patent
active
048959405
ABSTRACT:
An efficient, multistep process for the synthesis of 6-(1-hydroxyethyl) 2-thio-substituted penem antibiotics from 2-[4R-(triphenylmethy lthio)-3S-(1S-(dimethyl-t-butylsilyloxy)ethyl)-2-azetidon-1-yl]acetic acid esters.
REFERENCES:
patent: 4314942 (1982-02-01), McCombie
patent: 4443373 (1984-04-01), Girijavallabhan et al.
patent: 4443463 (1984-04-01), McCombie
patent: 4530793 (1985-07-01), Girijavallabhan et al.
patent: 4584133 (1986-04-01), Girijavallabhan et al.
patent: 4610823 (1986-09-01), DiNinno et al.
patent: 4614737 (1986-09-01), Hamanaka
patent: 4614738 (1986-09-01), Girijavallabhan et al.
patent: 4619924 (1986-10-01), Hamanaka
patent: 4673737 (1987-06-01), Evans et al.
patent: 4675317 (1987-06-01), DiNinno
patent: 4690922 (1987-09-01), Ganguly et al.
patent: 4739047 (1988-04-01), Volkmann et al.
patent: 4751297 (1988-06-01), Cue, Jr. et al.
patent: 4769451 (1988-09-01), Dextraze
patent: 4782145 (1988-11-01), Brighty et al.
Andrus et al., J. Am. Chem. Soc., 106, 1808-1811 (1984).
Afonso et al., J. Am. Chem. Soc., 104, 6138-6139 (1982).
Barker et al., Tet. Letters, 28, 2283-2286 (1987).
DiNinno et al., Tet. Letters, 23, 3535-3538 (1982).
Ganguly et al., J. Antimic. Chemoth., 9 (Suppl.), C1-C5 (1982).
Ghosez et al., Tetrahedron, 39, 2493-2503 (1983).
Girijavallabhan et al., J. Antibiot., 39, 1182-1190 (1986).
Girijavallabhan et al., Tet. Letters, 24, 3179-3182 (1983).
Leanza et al., Tetrahedron, 39, 2505-2513 (1983).
Marchand-Brynaert et al., Tet. Letters, 21, 3085-3088 (1980).
Ona et al., Chem. Pharm. Bull., 33, 4382-4394 (1985).
O'Neill Brian T.
Phillips Douglas
Blackwood Robert K.
Lumb J. Trevor
Pfizer Inc.
Richardson Peter C.
Rizzo Nicholas S.
LandOfFree
Process for the preparation of penems does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for the preparation of penems, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of penems will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-645938