Organic tricyclic compounds

Details Organic tricyclic compounds Organic tricyclic compounds

1975-12-11

1980-09-23

Hines, Robert V.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260349, 260456P, 260465R, 260465B, 2605011, 260544P, 260557R, 260558R, 260558P, 260561N, 260566A, 260566F, 260571, 2605709, 2605708TC, 424246, 4242484, 424267, 424274, 424316, 544 59, 544106, 546203, 560102, 562418, 562499, 568715, 568439, C07C 8728, A01N 924

Patent

active

042243440

ABSTRACT:
Novel 9-aminoalkyl-methanoanthracenes of the formula: ##STR1## wherein A is C.sub.1 -C.sub.4 alkylene or C.sub.3 -C.sub.4 alkenylene and R.sub.1 and R.sub.2 are each hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.4 alkenyl, C.sub.3 -C.sub.4 alkynyl, C.sub.3 -C.sub.6 cycloalkyl(C.sub.1 -C.sub.3)alkyl, ar(C.sub.1 -C.sub.3)alkyl or polyhalo(C.sub.2 -C.sub.4)alkyl or, when taken together with the adjacent nitrogen atom, they may form a 5 to 7-membered nitrogen-containing heterocyclic ring which may contain an additional hetero atom, and their non-toxic salts, which are useful as anti-anxiety, anti-depressant, major tranquilizer, anti-histamine and anti-allergy drugs and can be prepared through a novel key intermediate, i.e., 9-formyl-9,10-dihydro-9,10-methanoanthracene, by various methods.

REFERENCES:
patent: 3399201 (1968-08-01), Schmidt et al.
patent: 3622630 (1971-11-01), Craig et al.
patent: 3708525 (1973-01-01), Christy
patent: 3862131 (1975-01-01), Beck et al.
Chenier et al., "Journal Organic Chemistry", vol. 38, pp. 4350-4352 (1973).
Burger, "Medicinal Chemistry", 2nd Ed., pp. 82-83 (1960).

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