Biologically active tetracyclic compounds and pharmaceutical com

Details Biologically active tetracyclic compounds and pharmaceutical com Biologically active tetracyclic compounds and pharmaceutical com

1977-09-23

1980-09-23

Daus, Douglas G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260239BC, 260333, 260239D, A61K 3155, C07D24310

Patent

active

042243211

ABSTRACT:
Novel and biologically active tetracyclic compounds are disclosed of the formula: ##STR1## or a pharmaceutically acceptable non-toxic salt thereof, wherein R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are each hydrogen, hydroxy, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkylthio, halogen, or trifluoromethyl; R.sub.5 is hydrogen or C.sub.1 -C.sub.6 alkyl; and X is oxygen or methylene. Pharmaceutical compositions containing these compounds are disclosed to take advantage of CNS-inhibiting properties thereof, especially sedative and tranquillizing properties.

REFERENCES:
patent: 3465042 (1969-09-01), Hardtmann et al.
patent: 3534041 (1970-10-01), Van Der Burg et al.
patent: 3600392 (1971-08-01), Zust et al.
patent: 3892695 (1975-07-01), van der Burg

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