Process for the preparation of 7-acylamino-3-hydroxy-cephem-4-ca

Details Process for the preparation of 7-acylamino-3-hydroxy-cephem-4-ca Process for the preparation of 7-acylamino-3-hydroxy-cephem-4-ca

1984-07-31

1986-10-07

Pizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540222, 540301, 540360, 540203, C07D50102, A61K 31545

Patent

active

046160841

ABSTRACT:
A process for the preparation of a 7-acylamino-3-hydroxy-2-cephem-4-carboxylic acid, 7-acylamino-3-hydroxy-1-dethia-1-oxa-3-cephem-4-carboxylic acid or derivative thereof of the general formula ##STR1## in which R.sup.1 is hydrogen or optionally substituted alkyl, alkenyl, alkinyl, aralkyl, aryl, heteroaryl, heteroaralkyl, aryloxyalkyl, heteroaryloxyalkyl, alkoxyalkyl, arylthioalkyl, heteroarylthioalkyl, alkylthioalkyl, alkoxy, aryloxy, alkylthio or arylthio,

REFERENCES:
patent: 4174316 (1979-11-01), Christensen et al.
patent: 4346218 (1982-08-01), Tsujii et al.
patent: 4550162 (1985-10-01), Woodward et al.
Habich et al., Tetrahedron, vol. 40, No. 19, pp. 3667-3676 (1984).
Ghosez et al., Tetrahedron, vol. 39, No. 15, 2493-2502 (1983).

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