Compositions – Preservative agents – Anti-corrosion
Patent
1978-08-04
1980-09-23
Higel, Floyd D.
Compositions
Preservative agents
Anti-corrosion
8526, 8584, 8587, 252312, 252314, 252317, 252318, 252522R, 424 36, 424 94, 424177, 424199, 424319, 424180, B01J 1302
Patent
active
042241790
ABSTRACT:
A process for the preparation of a solution or suspension of liposomes in an aqueous medium comprising the steps of dispersing a first aqueous liquid in an essentially water-insoluble solvent in the presence of a compound of the formula XY wherein X is a hydrophilic lipophobic group and Y is a lipophilic hydrophobic group to form a dispersion of liposome precursors in the solvent, the precursors consisting of small vesicles of the first aqueous liquid surrounded by a monomolecular film of compound XY, emulsifying the liposome precursors in a second aqueous medium in the presence of a compound of the formula ZW wherein Z is a hydrophilic group and W is a hydrophobic group to thereby form a solution or suspension of liposomes in the second aqueous medium, said liposomes consisting of the first aqueous liquid surrounded by a bimolecular film of the structure XY-WZ and removing the water-insoluble solvent prior to after said emulsification.
REFERENCES:
patent: 3361680 (1968-01-01), Bohrer
patent: 4089801 (1978-05-01), Schneider
Tyrrell et al., Biochimica & Biophysica Acta, vol. 457, pp. 259-302, (1976).
Battelle (Memorial Institute)
Higel Floyd D.
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