Perhydromdole-2-carboxylic acids as antihypertensives

Details Perhydromdole-2-carboxylic acids as antihypertensives Perhydromdole-2-carboxylic acids as antihypertensives

1984-10-10

1986-10-07

Hendricks, Glenna M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548452, A61K 3140, C07D20942

Patent

active

046160299

ABSTRACT:
Compounds of the general formula: ##STR1## wherein: the ring A is saturated and n=0 or 1, or

REFERENCES:
patent: 3514465 (1970-05-01), Posselt et al.
patent: 4046889 (1977-09-01), Ondetti et al.
patent: 4105776 (1978-08-01), Ondetti et al.
patent: 4251444 (1981-02-01), Freed et al.
patent: 4256751 (1981-05-01), Hayashi et al.
patent: 4344949 (1982-08-01), Hoefle et al.
patent: 4350633 (1982-09-01), Kim et al.
patent: 4374829 (1983-02-01), Harris et al.
patent: 4508729 (1985-04-01), Vincent
Vincent, et al., "Stereoselective Synthesis . . . Perhydroindole . . . ," Tetrahedron Letters , vol. 23, pp. 1670-1680 (1982).
Burger, Alfred; Medicinal Chem., vol. I, pp. 75, 76, (1970).
Wollweber, et al., "Compounds Active on Blood Pressure", Chem Abst. 57:16561 (f), (1962).
Wagner and Zook; Synthetic Organic Chemistry, pp. 662, 663, (1953).
Patchett, et al., ". . . Angiotensin-Converting Enzyme Inhibitors", Nature, vol. 288, pp. 280-283, (1980).
The Merck Index, 9th Edition (1976), pp. 656, 657, Items 4840-4852.
Burger, Alfred; "Medicinal Chemistry", 3rd Edition, Part II, relating to Antihypertensive Agents, pp. 1019-1055.
Burger, Alfred; "Medicinal Chemistry", 4th Edition, Part III, relating to Antihypertensive Agents, pp. 324, 325.
Scriabine; "Pharmacology of Antihypertensive Drugs", relating to Guanethidine", pp. 127, 196, 211; and Alprenolol, p. 223; and Pindolol, p. 237; and, relating to Other Beta-Adrenoceptor Antagonists, pp. 350, 351.
Gross, et al.; "Journal of Pharmacology and Experimental Therapeutics" 1981, 216, (3), pp. 552-557.

Affiliated with

Also associated with

Rating

Perhydromdole-2-carboxylic acids as antihypertensives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Perhydromdole-2-carboxylic acids as antihypertensives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Perhydromdole-2-carboxylic acids as antihypertensives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-643586