Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1984-10-09
1986-10-07
Rosen, Sam
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
A61K 3748
Patent
active
046158855
ABSTRACT:
A pharmaceutical composition containing urokinase and a physiological absorption enhancer comprising higher fatty acids, a polyalkylene glycol and calcium is disclosed. Whereas urokinase which is decomposed and inactivated in the stomach and is poorly absorbed from the intestinal tract cannot be orally administered, it can be orally administered in the form of the present composition by applying an enteric coating, because urokinase in the composition is highly absorbable from the intestinal tract. It is desirable in the present composition in view of the stability and sustained absorbability that urokinase is contained in said composition in the form of a liposome preparation in which the urokinase is incorporated in voids of the liposome. The components are incorporated in the present composition at a ratio of 0.01-2 mg. of the higher fatty acid, 0.01-5 mg. of the polyalkylene glycol and 0.0001-0.1 mg. of the calcium per 100 units of urokinase. The present composition is satisfactory for use as a thrombolytic agent.
REFERENCES:
patent: 3050445 (1962-08-01), Damaskus et al.
patent: 3072532 (1963-01-01), Innerfield
patent: 3415804 (1968-12-01), Polson
patent: 3803304 (1974-04-01), Antonides
patent: 4258030 (1981-03-01), Sasaki
Green Cross-Chem. Abst., vol. 96 (1982), pp. 168, 735z.
Tanabe-Chem. Abst., vol. 97 (1982) p. 78900r.
Honda Haruo
Kimoto Tomoaki
Maruyama Teppei
Nakagame Fujio
Saito Noriko
Rosen Sam
Terumo Kabushiki Kaisha
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