Synthesis of artemisininelactol derivatives

Details Synthesis of artemisininelactol derivatives Synthesis of artemisininelactol derivatives

1989-02-27

1991-04-30

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D32102

Patent

active

050119516

ABSTRACT:
A process for the epimerization of .alpha.- to .beta.-ethyletherartemisininelactol (arteether) or preparation of arteether, useful in the treatment of malaria, from artemisininelactol, comprises reacting starting material in a solvent including an acid catalyst, the reaction of artemisininelactol also including an etherifying ethyl moiety, and isolating the product.

REFERENCES:
The Merck Index, 10th edition, Publ. Merck & Co., Rahway, N.J.; U.S.A. p. APP-3 (1983).

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