Morpholinoamido EDTA derivatives

Details Morpholinoamido EDTA derivatives Morpholinoamido EDTA derivatives

1989-09-05

1991-04-30

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544582, 544 60, 544 59, 544121, 544162, 544168, 544357, 544400, 562565, 562566, C07D29500, C07D41700, C07D41300, C07D24104

Patent

active

050119257

ABSTRACT:
Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with aminoalkylamide derivatives of diethylenetriaminepentaacetic acid ("DTPA") or ethylenediaminetetraacetic acid ("EDTA") or other polyaminocarboxylic or cyclic polyaminocarboxylic chelating agents. These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high solubilities in physiological solutions.
A novel method of performing an NMR diagnostic procedure involves administering to a warm-blooded animal an effective amount of a complex as described above and then exposing the warm-blooded animal to an NMR imaging procedure, thereby imaging at least a portion of the body of the warm-blooded animal.

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