Sustained pulsewise release pharmaceutical preparation

Details Sustained pulsewise release pharmaceutical preparation Sustained pulsewise release pharmaceutical preparation

1986-12-23

1991-04-30

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424425, 424484, 424485, 424486, A61F 200

Patent

active

050116924

ABSTRACT:
The invention relates to sustained pulsewise release pharmaceutical preparation which comprices drug-containing polymeric material layers (layers A) and polymeric material layers containing the drug in question only in a slight amount or free of the drug (layers B) disposed alternatingly, with the whole surface extending in the direction perpendicular to the layer plane being coated with a polymeric material which is insoluble in water or scarcely soluble in water (polymeric material C).
This pharmaceutical preparation of this invention is designed so that active ingredients which should desirably be released pulsewise can be released therefrom in a pulse-like and clinically significant manner and thereby the pharmacological effects of said active ingredients can be maintained for a prolonged period of time.

REFERENCES:
patent: 4217898 (1980-08-01), Theeuwes
patent: 4359483 (1982-11-01), Kaetsu
patent: 4439196 (1984-03-01), Higuchi
patent: 4559054 (1985-12-01), Bruck
patent: 4564364 (1986-01-01), Zaffaroni et al.
patent: 4627850 (1986-12-01), Deters et al.
patent: 4663147 (1987-05-01), DePrince
Langer, Journal of Membrane Science, 7, 333-350, 1980.

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