N-phenyl-2-cyano-3-hydroxy-propenamides

Details N-phenyl-2-cyano-3-hydroxy-propenamides N-phenyl-2-cyano-3-hydroxy-propenamides

1994-06-06

1995-05-16

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514466, 514522, 549434, 549436, 549438, 549439, 549441, 558392, A61K 31275, C07C25523

Patent

active

054161126

ABSTRACT:
A compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms and alkenyl and alkynyl of 2 to 6 carbon atoms, R.sub.2 is hydrogen or alkyl of 1 to 3 carbon atoms, Y is selected from the group consisting of ##STR2## Z.sub.1 and Z.sub.2 are individually selected from the group consisting of hydrogen, halogen, --NO.sub.2, --CN and alkyl of 1 to 3 carbon atoms, R.sub.3 is hydrogen or alkyl of 1 to 3 carbon atoms, m is an integer from 0 to 6, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are individually selected from the group consisting of hydrogen, halogen, --CN, --NO.sub.2, alkyl, alkylthio and alkoxy of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, --COR.sub.10, --(CH.sub.2).sub.n --CX.sub.3, --O--(CH.sub.2).sub.n CX.sub.3 and --S--(CH.sub.2).sub.n --CX.sub.3, R.sub.10 is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and cycloalkyl of 3 to 6 carbon atoms, n is an integer from 0 to 3, X is halogen or R.sub.6 and R.sub.7 together form --O--CH.sub.2 --O-- and their non-toxic, pharmaceutically acceptable salts with a base having anti-inflammatory and immunomodulatory activity.

REFERENCES:
patent: 5240960 (1993-08-01), Hambleton et al.
patent: 5308865 (1994-05-01), Bartlett et al.
patent: 5312830 (1994-05-01), Kuo
Axton, et. al., Chem. Soc. Perkin. Trans. 1(1992), pp. 2203-2213.

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