Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-05-19
1995-05-16
Chang, Celia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514337, 514397, 514414, 514422, 546196, 546269, 5483114, 548454, 548472, C07D40514, A61K 3140, A61K 3141, A61K 31445
Patent
active
054160979
ABSTRACT:
This invention relates to novel potassium channel activators and their acid addition salts. The compounds of the invention as potassium channel activators/openers have therapeutic value in a number of physiological areas such as hypertension, cardiac ischemia, cerebral ischemia, broncho constriction and neurodegenerative diseases. Pharmaceutical compositions are proposed for the compounds which are of the following formulae: ##STR1## wherein: R is H or OH;
- - - the dotted line at position 3,4 represents the presence or absence of a double bond. ##STR2## the pharmaceutically acceptable acid addition salts thereof, with the provisos that:
a) R is H when 3,4 is a double bond; and
b) R is OH when 3,4 is a single bond.
REFERENCES:
patent: 4446113 (1984-05-01), Evans et al.
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patent: 4908378 (1990-03-01), Soll
patent: 5118694 (1992-06-01), Attwood
patent: 5189047 (1993-02-01), Hadley
Bergmann et al "Synthesis and antihypertensive Activity of 4-(1,2-dihydro-2oxo-1pyridyl)-2H-1-benzopyrans and Related Compounds, New Potassium Channel Activator" J. Med Chem. 33 492-504 (1990).
Erhardt Paul W.
Shaw Kenneth J.
Bellamy Elizabeth A.
Berlex Laboratories Inc.
Chang Celia
Sopp John A.
White John L.
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