Process for preparing quinazolones

Details Process for preparing quinazolones Process for preparing quinazolones

1996-02-05

1998-04-14

Grumbling, Matthew V.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544287, C07D23988, C07D23970

Patent

active

057393303

ABSTRACT:
The present invention provides a process for preparing a quinazolone which comprises the steps of (a) dehydrating a N-acyl beta amino acid in the presence of a dehydration agent and an organic solvent for a sufficient period of time and under suitable temperature and pressure conditions to form an oxazone (b) adding a carboxylic acid and a primary amine salt of a carboxylic acid to said oxazone to form a mixture, (c) distilling azeotropically said mixture for a suitable period of time and under suitable temperature and pressure conditions to substantially remove said dehydration agent and said organic solvent, and (d) heating the product of step (c) for a sufficient period of time and under suitable temperature and pressure conditions to form said quinazolone.

REFERENCES:
patent: 3714354 (1973-01-01), Stam
patent: 3793326 (1974-02-01), Muren
patent: 4695569 (1987-09-01), Janssens et al.
patent: 4981856 (1991-01-01), Hughes et al.
patent: 5025014 (1991-06-01), Janssens et al.
patent: 5126339 (1992-06-01), Janssens et al.
patent: 5610299 (1997-03-01), Blum et al.

Affiliated with

Also associated with

Rating

Process for preparing quinazolones does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing quinazolones, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing quinazolones will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-636211